Study on the relationship between personality characteristics and family environment of medical undergraduates taking psychology as an elective course / 四川精神卫生

ObjectiveTo analyze the correlation between personality characteristics and family environment of undergraduate medical students taking psychology course. MethodsIn June 2017， a cross-sectional survey was conducted among 67 undergraduate medical students taking psychology course， and all the selected individuals were assessed using Minnesota Multiphasic Personality Inventory （MMPI） and Family Environment Scale-Chinese Version （FES-CV）. Then Pearson correlation analysis was performed between the original scores of MMPI subscales and the scores of FES-CV subscales. ResultsThe scores of hypochondriasis， depression， hysteria， psychopathic deviate， masculine-femininity， paranoia， psychasthenia and schizophrenia in MMPI of undergraduates were all higher than those of the national norm， with statistical differences （t=2.070~8.350， P<0.05 or 0.01）. The scores of cohesion， intellectual-cultural orientation， organization and achievement orientation in FES-CV of undergraduates were all lower than those of the national norm， while the scores of conflict tendency was higher than that of the national norm， with statistical differences （P<0.05 or 0.01）. Correlation analysis showed that cohesion score in FES-CV was negatively correlated with the scores of correction， hypochondriasis， depression and hysteria in MMPI （r=-0.410~-0.331， P<0.01）. Conflict tendency score was positively correlated with the scores of hysteria and psychasthenia （r=0.315， 0.415， P<0.01）. Active-recreational orientation score was negatively correlated with hypochondriasis score （r=-0.367， P<0.01） and positively correlated with schizophrenia score （r=0.346， P<0.01）. Control score was positively correlated with hysteria score （r=0.366， P<0.01）. ConclusionUndergraduate medical students taking psychology courses exhibit neuropathic and paranoid personality characteristics， and the personality characteristics are closely related to family environment.

Analysis on risk factors of methicillin-resistant staphylococcus aureus enterocolitis after gastrointestinal surgery / 中华胃肠外科杂志

OBJECTIVE@#To investigate the risk factors of methicillin-resistant Staphylococcus aureus(MRSA) enterocolitis after gastrointestinal surgery.@*METHODS@#Clinical and pathological data of 17 cases with MRSA enteritis after gastrointestinal surgery from March 2015 to March 2017 at Department of General Surgery of Affiliated Drum Tower Hospital were retrospectively analyzed.@*INCLUSION CRITERIA@#(1) age of 18 to 80 years;(2) with history of gastrointestinal surgery; (3) diarrhea symptoms within 7 days after gastrointestinal surgery; (4) use of antibiotics before diarrhea; (5) fecal smear showing a large number of gram positive cocci; (6) fecal culture suggested the presence of MRSA; (7) application of antibiotic therapy against MRSA was effective.@*EXCLUSION CRITERIA@#(1)clostridium difficile toxin positive; (2) toxic shock syndrome caused by food poisoning. According to gender, age, and inpatient ward, 1:2 pairing was performed, and 34 patients with non-MRSA enteritis from the hospitalized cases in the same ward were selected as the control group for retrospective case-control study. There were no significant differences in the gender, age, and constitution index between two groups (all P>0.05), indicating that the two groups were comparable. The χ² test was used to perform univariate analysis on 11 factors, including the nature of the primary disease, colorectal surgery, emergency surgery, use of multiple antibiotics, preoperative bowel preparation, perioperative hormone, intraoperative intraperitoneal chemotherapy, perioperative nasogastric tube, diabetes history, intensive care unit stay, and previous infectious disease hospitalization, and then multivariate logistic regression analysis was performed.@*RESULTS@#MRSA enteritis occurred 3 to 5 days after surgery in all the 17 cases, and 4 cases developed septic shock rapidly. Univariate analysis showed that the operation site (colorectal surgery) (χ²=4.747, P=0.029) and use of two antibiotics before MRSA enteritis (χ²=3.959, P=0.047) were associated with MRSA enteritis after gastrointestinal surgery. Multivariate logistic regression analysis revealed that colorectal surgery was the only independent risk factor for MRSA enteritis after gastrointestinal surgery(OR=5.526, 95%CI: 1.350-22.602,P=0.017), while the use of two antibiotics was not (OR=0.204, 95%CI:0.051-0.819, P=0.025).@*CONCLUSIONS@#MRSA enteritis has a rapid onset, and a high incidence of septic shock, which requires immediate attention. Colorectal surgery is an independent risk factor for MRSA enteritis.

Analysis of clinicopathological features and prognosis in 30 cases with multifocal gastric cancer / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To study the clinicopathological features and prognosis of multifocal gastric cancer.</p><p><b>METHODS</b>Clinicopathological data of 30 cases with multifocal gastric cancer from January 2003 to March 2014 in our department were retrospectively analyzed. Random selection of 100 cases of single focal gastric cancer patients admitted in the same period was used as control group. Clinicopathological features and prognosis were compared between two groups.</p><p><b>RESULTS</b>Six(20.0%) multifocal gastric cancer patients had 3 or more focuses with different differentiation degrees at the same time. The age of multifocal gastric cancer patients was younger than that of single focal gastric cancer [(56.8±16.4) year vs. (63.3±10.8) year, P<0.05]. The TNM stage of multifocal gastric cancer was mainly stage I((73.3%, 22/30), and the TNM stage of single focal gastric cancer was mainly stage III((64.0%, 64/100). As compared to single focal gastric cancer group, multifocal gastric cancer group had smaller tumors, lower ratio of nerve invasion and lymphatic vascular invasion(all P<0.01). Five-year survival rate was higher in multifocal gastric cancer group as compared to single focal gastric cancer group(76.0% vs. 48.8%, P<0.05). The prognosis of multifocal gastric cancer patients was associated with tumor size, nerve invasion, vascular invasion, depth of tumor invasion, lymphatic metastasis and TNM staging(all P<0.05), which was similar to single focal gastric cancer patients. Differences of 5-year survival rate under various clinicopathological conditions were not significant between two groups(all P>0.05).</p><p><b>CONCLUSION</b>Multifocal gastric cancer patients have earlier staging tumor and overall advantage as compared to those with single focal gastric cancer.</p>

Research on effect of central 5-HTergic system in early-onset depression / 中国药理学通报

Nowadays the pathogenesis of early-onset depression is still uncertain. Only SSRIs are currently approved for clinical use as antidepressants in children and adolescents, indicating that 5-HT is the most important neurotransmitter involved in the dis-ease. Current studies with regard to central 5-HTergic system in early-onset depression mainly focus on 5-HT synthesis deficien-cy, 5-HT transportation dysregulation, as well as the earlier mat-uration of 5-HT system than norepinephrine system. 5-HT precur-sor tryptophan malabsorption and dysregulation of 5-HT synthesis can contribute to 5-HT deficiency. Moreover, the 5-HTTLPR low-expressing genotypes may increase the risk of early-onset de-pression. It is necessary to make preclinical and clinical studies more widely and deeply about the effect of central 5-HTergic sys-tem in early-onset depression in future.

Diagnosis and analysis of residual gallbladder stone with choledocholithiasis / 中国基层医药

Objective To investigate the diagnosis/misdiagnosis reason/treatment of residual gallbladder stone with choledocholithiasis.Methods The clinical data of 34 patients with residual gallbladder,16 cases of them suffered from choledocholithiasis additionally were retrospective analyzed.Results 14 cases were treated by residual cholecystectomy +choledochotomy +T -tube drainage,2 cases were were treated by choledochotomy + T -tube drainage.Preoperative misdiagnosis of residual gallstones rate was 56.3% (9 /16 ),7 cases were found residual gallstones during operation.The other 2 cases were misdiagnosed residual gallstones.The rate of intraoperative and postoperative misdiagnosis was 12.5% (2 /16 ).18 cases with residual gallstones,16 cases underwent residual cholecystectomy,2 cases who were suspected with choledocholithiasis underwent residual cholecystectomy +choledo-chotomy,T -tube drainage.18 cases had no preoperative and postoperative misdiagnosis.Conclusion The clinical symptom of residual gallbladder stone with choledocholithiasis was similar to residual gallstones,often characterized by upper abdominal pain,fever,chills,jaundice,abdominal distension and other symptoms.It is difficult for preoperative imageological diagnosis that less than 3 cm residual gallbladder and small stones.When choledocholithiasis at the same time,needing more intraoperative careful dissect cystic duct and common bile duct,completes the cystic duct and common bile duct exploration,reducing misdiagnose residual gallstones.

Improving prolene hernia system tension-free repair for inguinal hernia under ultrasound-guided local nerve block anesthesia / 国际外科学杂志

Objective To investigate the application of improving prolene hernia system(PHS) tensionfree repair for inguinal hernia under ultrasound-guided local nerve block anesthesia.Methods Retrospective analysis the clinical data of 40 patients with improving prolene hernia system(PHS) tension-free repair for inguinal hernia under ultrasound-guided local nerve block anesthesia from January 2013 to January 2014 in Gulou Hospital of Nanjing University.Results In group of ultrasound-guided local nerve block anesthesia , the average anesthesia time was (8.9 ± 1.5) min, the time to get out of bed was (5.6 ± 1.1) h, the length of stay was (2.9 ± 0.7) d,There were (12.4 4± 2.2) min, (10.2 ± 1.6) h and (3.7 ±± 0.7) d in general anesthesia group, and significant difference(P ＜0.05), the average operation time of two groups were (22.6 ± 2.0) min, (22.1 ± 2.4) min,the average duration of postoperative analgesia was (6.4 ± 1.6) h, (6.1 4± 1.5) h, and no significant difference (P ＞ 0.05).Conclusions Improving prolene hernia system(PHS) tension-free repair for inguinal hernia under ultrasound-guided local nerve block anesthesia is simple , easy and safe to be performed with mild pain, faster recovery and less bleeding.It is worthy of popularization and application.

Progress of diagnosis, treatment and prognosis of four special kinds of gastric cancer / 国际外科学杂志

Except common histologic type,some special histological types and clinico-pathological features of gastric cancer,such as neuroendocrine carcinoma,hepatoid adenocarcinoma,lymphoepithelioma-like gastric carcinoma and hereditary diffuse gastric cancer,etc,because of there special diagnosis and treatment measures and prognosis,should be taken into account in our clinical work.This article reviews the clinical progress of diagnosis,treatment and prognosis of the four special kinds of gastric cancer mentioned above.

Role and mechanism of XRCC4 in the genesis and development of tumor / 国际外科学杂志

DNA double-strand breaks(DSBs) repair protein XRCC4,plays an important role in the genesis and development of tumor,there are many different aspects in the tumor genesis and development.This paper reviews the molecular mechanism of XRCC4 in repairing DSBs,several theories of tumor genesis and development,and the relationship between XRCC4 gene's single nucleotide polymorphisms(SNPs) and tumor.

Observation on the effect of decompression in the treatment of large jaw cystic lesions / 中国基层医药

Objective To investigate the clinical efficacy and safety of decompression in the treatment of large jaw cystic lesions.Methods 42 patients suffered from large jaw cystic lesions were randomly divided into two groups,21 patients in the control group performed the traditional curettage surgery;21 patients in the experiment group performed the decompression surgery.The intraoperative blood loss,operative time,the incidence rate of postoperative pain and postoperative infection,follow-up recurrence rate were compared between the two groups.Results The intraoperative blood loss,operative time,postoperative pain and postoperative infection rates of the experiment group were significantly better than the control group,the differences between two groups were significant(P ＜ 0.05).The recurrence rate of the control group and the experiment group was 24.0％,4.8％.The recurrence rate of the experiment group was significantly lower than the control group (P ＜ 0.05).Conclusion Compared to the traditional curettage surgery,decompression surgery can reduce blood loss,shorter operative time,reduce postoperative infection,reduce the risk of recurrence,then improve the clinical efficacy.

Effect of Bcl-2 and Bax protein expression on the apoptosis of renal tubular epithelia in rats with obstructive jaundice / 西安交通大学学报(医学版)

Objective To investigate the relationship of the expression of Bcl-2 and Bax protein with apoptosis of renal tubular epithelia in rats with obstructive jaundice(OJ).Methods A total of 60 adult Sprague-Dawley(SD) rats were divided into two groups: OJ rats by ligating bile duct(OJ group,n= 40) and the sham-operation rats(the control group,n=20).The two groups of rats were sacrificed at postoperative 1,2,3 and 4 week,respectively.Then serum BUN and Cr levels were tested and renal histopathological and ultrastructural changes were observed.Apoptosis of renal tissues was assayed by TUNEL method.The immunohistochemical Elivision~(TM) technique was adopted for detecting the Bcl-2 and Bax protein expression.Results With the time of OJ prolonging,the value of serum BUN and Cr increased;apoptotic cells of renal tubular epithelia increased.There were obvious differences in Bcl-2 and Bax protein expression of between OJ and control groups(P

Experiment Study on the Quality Standard and Formulation Screening of Bergenin Tablets / 中国药房

OBJECTIVE:To screen the optimum formulation of bergenin tablet and to establish an analysis method for measuring the content of bergenin in the tablets METHODS:The L3(34) orthogonal table and the parameter of in vitro dissolubility(Td) was employed to select the optimum formulation by taking LS-HPC,tween-80-starch,and starch as the three main factors,and three levels were adopted for each-factor The dual-wavelength spectrophotography was employed to determine the content of bergenin in the tablets RESULTS:The experimental results indicated that LS-HPC and tween-80-starch were the chief factors of influencing dissolution of tablet(P0 05) The optimum formulation was composed of bergenin:0 125g,Ls-HPC:0 0 186g,tween 80-starch:0 0 248g,starch:0 1 354g,magnesium stearate:0 0 032g The dual-wavelength spectrophotography was convenient and accurate The average recovery rate of bergenin was (100 92?0 87)%(n=8) CONCLUSION:The formulation has merits of low price of supplementary materials,rapid release of effective component,simple manufacture technique,and stability in quality

Study on the Formula Selection of Total Alkaloid Tablets of Peganum Harmala by Orthogonal Design / 中国药房

OBJECTIVE:To optimize the best formula of the total alkaloid tablets of peganum harmala.METHODS:3 levels from each of the amount of four factors-excipient calcium carbonate,tween-80,starch and emollient(magnesium stearate:french chalk) were subjected to the orthogonal design with the parameter of dissolution(Td) of the harmine in tablet as an index.RESULTS:The amount of tween-80 and calcium carbonate(P

Observation on apoptosis of renal cell in the rat with obstructive jaundice and salvia miltiorrhiza's effect on apoptosis / 西安交通大学学报(医学版)

Objective To investigate the function of apoptosis in the renal injury by observing change of renal pathology and ultrastructure in the rat with obstructive jaundice(OJ) and if salvia miltiorrhiza(SM) can lighten the renal dysfunction of obstructive jaundice.Methods A total of 100 adult Sprague-Dawley rats were studied.Among them,the 80 models of obstructive jaundice were established by ligating bile duct(BDL),then divided into two groups: the OJ rats administered daily abdomen injections of SM(1.7g per rat) after operation of bile duct ligation(the SM group,n= 40);the OJ rats receiving only the same normal saline(the OJ group,n=40).The other rats with sham operation receiving only normal saline(the control group,n=20).Three groups of rats were sacrificed in groups at postoperation 1,2,3 and 4 week,respectively.Then serum BUN & Cr were tested and renal change of histopathology and ultrastructure were observed;Apoptosis of renal tissue were assayed by TUNEL method.Results With the time of BDL extending,the value of serum BUN & Cr increased;Apoptotic cells increased in renal tissue.After treatment with SM,the injury degree of renal function and histopathologic changes decreased.Conclusion Obstructive jaundice can lead to renal injury.Apoptosis had an important effect on renal function injury in the rat with obstructive jaundice.Salvia miltiorrhiza can ease the degree of renal function injury.